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Valbenazine's Consistent But Weak Effect In Tourette Dismays Neurocrine

 
• By John Davis

In "very top-line" Phase IIb data, the magnitude of the treatment effect for valbenazine in children with Tourette syndrome was weaker than expected, and its loss from active development means there will be only a handful of candidates under evaluation for the disorder.

Gold
The T-Force GOLD Phase IIb results have disappointed Neurocrine • Source: Shutterstock

Tourette syndrome is proving a difficult disorder to crack by pharmacological means. US biotech Neurocrine Biosciences Inc. has again reported disappointing early-stage clinical results in the disorder with its neurological, valbenazine, this time in top-line data from T-Force GOLD, a Phase IIb study in pediatric patients.

This time around dosing wasn't considered to be an issue, leading analysts to conclude valbenazine is unlikely to show sufficient clinical benefit in further studies

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