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Sage Impresses With Second Postpartum Depression Therapy

 
• By John Davis

Positive top-line Phase III data with Sage's second lead positive allosteric modulator at GABA receptors, SAGE-217, in postpartum depression continues to back the US biotech's approach to the devastating condition.  

Depression
Postpartum depression can be devastating for mothers and their families • Source: Shutterstock

The value of Cambridge, Mass.-based SAGE Therapeutics Inc.'s shares surged by 50% on Jan. 7 as the CNS-focused biotech released positive top-line Phase III results for its second lead compound, the orally administered SAGE-217, in postpartum depression, and the company's management presented an update of its commercial strategy at the J. P. Morgan Healthcare conference.

As well as the positive data, analysts attributed some of the excitement surrounding the company to it being a potential...

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