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Merck’s Keytruda Shows Utility In Subset Of Esophageal Cancer

 
• By Joseph Haas

A Phase III study testing Keytruda monotherapy in second-line esophageal cancer versus physician’s choice of chemotherapy shows a 31% reduction in risk of death for patients expressing PD-L1. [Editor's Note: Article updated to clarify trial outcomes.]

Cancer cells on scientific background.3d illustration

Merck & Co. Inc. plans to seek supplemental approval for its anti-PD-1 therapy Keytruda in second-line esophageal cancer based on successful data from a Phase III study testing pembrolizumab monotherapy versus physician’s choice of chemotherapy, after the trial showed statistical significance in improving overall survival in patients whose tumors express PD-L1.

The trial was designed to be deemed successful if it proved any of three primary hypotheses pertaining to overall survival...

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