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AC Immune/Roche Drop Crenezumab After Phase III CREAD Alzheimer's Failure

 
• By John Davis

Interim top-line data from CREAD 1 and 2 indicate crenezeumab is unlikely to meet its primary endpoints and the studies are being stopped, but a clinical study in Colombia in familial Alzheimer’s is set to continue.

Brain
• Source: Shutterstock

Roche is discontinuing two Phase III clinical studies of crenezumab after an independent interim analysis concluded the anti-beta amyloid monoclonal antibody is unlikely to meet the studies’ primary endpoints, news that continues a long-line of clinical trial disappointments in this therapeutic sector. 

Crenezumab was being developed in collaboration with the originator, the Swiss biotech, AC Immune SA, and the failure is likely to “weigh heavily on both Roche but particularly partner AC Immune,” commented analysts

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