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Nektar/Bristol Show Promise With Double IO Combo, But Numbers Are Small

 
• By Emily Hayes

Updated data from PIVOT-02 at the ASCO GU meeting suggest a path for accelerated approval of the NKTR-214/Opdivo combination as first-line treatment of patients with PD-L1-negative urothelial cancers.

Bladder cancer medical concept as an anatomical organ symbol with microscopic malignant cells spreading in the human body as a health care 3D illustration.

It's still early days yet and the numbers are very small, but the double immuno-oncology combination of Nektar Therapeutics' NKTR-214 in combination with Bristol-Myers Squibb Co.'s PD-1 inhibitor Opdivo for advanced urothelial cancer has potential to treat the sizeable population of patients with low PD-L1 expression, based on updated results from the Phase I/II PIVOT-02 study.

Bristol’s well-established checkpoint inhibitor is being paired with a new immuno-oncology (IO) agent: NKTR-214 is a CD-122 agonist, targeting one of the components of IL-2 receptors found on the...

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