Reata Expands Options For Bardoxolone With New CKD Data

 
• By Joseph Haas

Once suspended due to safety issues, bardoxolone now has completed a Phase II study that showed kidney function benefit in four rare types of CKD. A pivotal study is underway, with another planned and more possible.

Human kidney on scientific background. 3d illustration

Reata Pharmaceuticals Inc.’s bardoxolone methyl continued its rise from the ashes, as the antioxidant inflammation modulator (AIM) showed kidney function benefit in the fourth and final chronic kidney disease (CKD) indication studied in the Phase II proof-of-concept PHOENIX study.

The firm terminated a 2,000-patient, Phase III study of bardoxolone in 2012 due to a high rate of adverse events...

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