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Vertex Stuck Between A Good Place And A Better Place

 
• By Joseph Haas

Two three-drug regimens for cystic fibrosis hit their primary endpoints in both heterozygous and homozygous patients, with good safety and tolerability, which analysts say increases the likelihood one of them will obtain approval.

Los Angeles, California, USA - 28 February 2019: Vertex Pharmaceuticals website homepage. Vertex Pharmaceuticals logo visible on display screen, Illustrative Editorial - Image

Vertex Pharmaceuticals Inc. may not yet have certainty on which of two three-drug combination regimens for cystic fibrosis it will file for approval in the US and Europe, but it at least has options. A second three-drug combo hit the primary endpoints in a pivotal Phase III study a few months after its first trio did the same, and now Vertex says it will wait for 24-week data to decide which regimen it will file for approval.

On March 6, the Boston specialty pharma revealed that a combination of next-generation CFTR (cystic fibrosis transmembrane conductance regulator) corrector...

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