Germany’s Adrenomed has set itself the goal of cutting the death rate from sepsis by 50%. It is awaiting results from a 300-patient proof of concept Phase II study of its first-in-class monoclonal antibody adrecizumab later this year, after successfully clearing an interim analysis. Chief business officer Frauke Hein discusses the company’s work in septic shock, and explains how its focus on targeting endothelial dysfunction and rescuing vascular integrity lends itself to other diseases, such as acute heart failure.
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