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In Hindsight, Savara Wishes It Led With Patient-Reported Secondary Endpoint For Molgradex

 
• By Joseph Haas

Orphan lung disease firm tries to sell Phase III setback in aPAP as a “successful failed study” but investors disagree, cutting Savara’s share price by three-quarters. Biotech hopes to talk with regulators after deeper dive into dataset.

human-lungs
Savara specializes in orphan lung disease indications

It’s fairly standard for a biotech to frame a study that missed its primary endpoint as offering promise on other measures, but Savara Inc.’s attempt to depict its unsuccessful Phase III IMPALA study of Molgradex in autoimmune alveolar pulmonary proteinosis (aPAP) as a “successful failed study” is not resonating with investors.

The Austin, TX-based biotech reported after market closing on 12 June that Molgradex – an inhaled recombinant formulation of human...

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