Calithera Biosciences Inc.’s telaglenastat (CB-839) has doubled median progression-free survival (PFS) in heavily pre-treated patients with advanced renal cell carcinoma (RCC) when used in combination with everolimus in the Phase II ENTRATA study, top-line data show.
This makes telaglenastat the first glutaminase inhibitor to demonstrate clinical activity for the treatment of cancer. The drug is designed...