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Karyopharm’s Xpovio In Multiple Myeloma Priced At $22,000 Per Four-Week Cycle

 
• By Joseph Haas

Immediate interaction with US FDA after stressful advisory committee facilitated accelerated approval in fourth-line myeloma, company says. Four different dosing regimens will be priced at $22,000 for four weeks.

FDA approved
Karyopharm's accelerated approval now awaits confirmatory Phase III data

Karyopharm Therapeutics Inc. obtained approval for Xpovio (selinexor) to treat penta-refractory multiple myeloma patients on 3 July, with a full approval hinged on the ongoing Phase III BOSTON trial, despite safety concerns and other issues overhanging the drug.

Pessimism reigned regarding the chances for the first-in-class nuclear export inhibitor to gain accelerated approval following a US FDA advisory committee review in February, but investors turned optimistic as the...

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• By Jung Won Shin

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GSK’s Bet On Spero’s Oral cUTI Antibiotic Poised To Pay Off With New Phase III Data

 
• By Joseph Haas

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