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GSK's Otilimab Goes Head-To-Head To Crack Rheumatoid Arthritis

 
• By John Davis

GlaxoSmithKline is exploring a potential new way of tackling rheumatoid arthritis in just-started Phase III studies which could shake up a disease sector that is already attracting interest from other big pharma companies.  

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Rheumatoid arthritis can cause painful deformities. • Source: Shutterstock

The Phase III clinical trial program for GlaxoSmithKline PLC’s novel mechanism-of-action rheumatoid arthritis candidate, otilimab (GSK3196165), will include head-to-head comparisons with marketed RA therapies including Pfizer Inc.’s oral JAK inhibitor, Xeljanz (tofacitinib), and Sanofi/Regeneron Pharmaceuticals Inc.’s injectable anti-interleukin-6 Mab, Kevzara (sarilumab), the UK big pharma announced on 3 July.

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• By Alaric DeArment

BMS’s Phase III ODYSSEY-HCM study did not show statistical significance for either of its two primary endpoints.