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GSK's Otilimab Goes Head-To-Head To Crack Rheumatoid Arthritis

 
• By John Davis

GlaxoSmithKline is exploring a potential new way of tackling rheumatoid arthritis in just-started Phase III studies which could shake up a disease sector that is already attracting interest from other big pharma companies.  

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Rheumatoid arthritis can cause painful deformities. • Source: Shutterstock

The Phase III clinical trial program for GlaxoSmithKline PLC’s novel mechanism-of-action rheumatoid arthritis candidate, otilimab (GSK3196165), will include head-to-head comparisons with marketed RA therapies including Pfizer Inc.’s oral JAK inhibitor, Xeljanz (tofacitinib), and Sanofi/Regeneron Pharmaceuticals Inc.’s injectable anti-interleukin-6 Mab, Kevzara (sarilumab), the UK big pharma announced on 3 July.

The breadth of the program is one of the clearest signs yet of the effort GSK is continuing to put into developing the investigational rheumatoid arthritis therapy, which, as an anti-granulocyte macrophage colony stimulating factor (GM-CSF)

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