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Road Ahead Unclear For Polyphor’s Intravenous Murepavadin

 
• By Alexandra Shimmings

The Swiss firm is still examining options for the iv formulation of its novel antibiotic murepavadin even after it closed its two Phase III studies on safety concerns.

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• Source: Shutterstock

Polyphor Ltd. has decided to close the two Phase III trials of murepavadin iv for hospital-acquired and ventilator-associated bacterial pneumonia (HABP/VABP) that were put on a voluntary temporary hold in May, spelling the likely end for the program.

The Phase III trials – PRISM-MDR and PRISM-UDR – were evaluating murepavadin in patients with nosocomial pneumonia but a higher...

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