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J&J Drops Alligator’s MAb ADC-1013 After Reviewing Combination Data

The anti-CD40 antibody underperformed in some preclinical cancer combination studies, leading J&J to prioritize other assets. Alligator Bioscience will now advance ADC-1013 while seeking a new partner.

Returned
Janssen had gained exclusive rights for ADC-1013 in 2015 • Source: Shutterstock

Sweden-based Alligator Bioscience AB put on a brave face when announcing Johnson & Johnson's Janssen Biotech Inc. unit had handed back rights to its experimental CD40 agonistic antibody, ADC-1013, and said it will now “rapidly advance” the tumor-directed immunotherapy candidate to Phase II trials while looking for a replacement partner.

Janssen had gained exclusive rights to develop and commercialise ADC-1013, also known as JNJ-64457107, under a deal signed in 2015.

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