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Nektar Pins Falling Cancer Response Rate On Manufacturing Problem

A post-hoc analysis linked “physical differences” in two lots of Nektar’s drug to lower efficacy when given in combination with Bristol-Myers Squibb’s Opdivo. Nektar’s share price tumbled following the update.

Bad apple
Nektar says two bad lots contaminated trial data

Nektar Therapeutics has blamed manufacturing quality problems for falling response rates in a study of patients receiving its immuno-oncology drug bempegaldesleukin.

Early in a Phase I/II trial, the pegylated version of human recombinant interleukin 2 (IL-2), formerly known as NKTR-214, achieved a 63% response rate when given with Bristol-Myers Squibb...

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