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Inrebic Approval Is A Boost For Myelofibrosis And Celgene's Buyer Bristol

 
• By Mandy Jackson

Investors in Impact Biosciences, which sold the selective JAK2 inhibitor to Celgene for $1.1bn up front, could double their money with milestone fees based on fedratinib's approval.

Diagnosis of Myelofibrosis. Laboratory blood bottle (tube), glass slide with blood smear, hematology test, stethoscope lying on notebook with printed text hematological diagnosis of Myelofibrosis - Image
Inrebic is only the second drug, after Jakafi, approved for myelofibrosis in the US. • Source: Shutterstock

Ownership of Inrebic (fedratinib) traded hands a few times before it landed at Celgene Corp. for $1.1bn up front in January 2018, so with US Food and Drug Administration approval of the selective JAK2 inhibitor on 16 August it's not just myelofibrosis patients – who haven't had a new drug for their disease in eight years – that will benefit.

Inrebic was approved via priority review two and a half weeks before its 3 September action date to treat US adults with intermediate-2 or high-risk primary or secondary

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