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Synlogic Pivots After First Clinical Failure

 
• By Jessica Merrill

The synthetic biotics company is discontinuing development of SNYB1020, its first clinical-stage product, which failed to lower blood ammonia in cirrhosis patients.

missed-target
Synlogic's first clinical-stage drug missed its mark • Source: Shutterstock

Synlogic Inc. is discontinuing development of its first clinical-stage asset, SYNB1020 for the treatment of hyperammonemia, after it failed to show a benefit in a Phase Ib/IIa study. The development is a disappointing one for the company, which has been pioneering the development of a new class of synthetic biotic medicines that work in the microbiome since it was established in 2014.

The Cambridge, Mass.-based company is pivoting to focus on advancing two other early clinical-stage programs instead: SYN1618 for the treatment...

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