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What Else Analysts Want To Know About Phase III Data For TMC’s Inclisiran

 
• By Joseph Haas

Looking to be a game-changer with a highly effective LDL-C-lowering agent dosed twice annually, The Medicines Company says inclisiran met efficacy endpoints in a large Phase III study. But observers await fuller data, including safety details.

LDL (Bad) Cholesterol level chart on a table. - Image
TMC hopes inclisiran can reduce LDL-C levels with twice-annual dosing

Top among the things analysts want to see when additional data for The Medicines Co.’s inclisiran are presented next week are the magnitude of the efficacy results for the RNA-interference therapy and a clear understanding of the safety profile, especially liver toxicity.

The Medicines Co. released topline Phase III results from the ORION-11 study, the first in a three-trial program, on 26 August – just ahead of the presentation of more detailed...

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