Inclisiran’s Safety Data Suggest Game-Changing Potential In PCSK9 Market

The Medicines Co. unveiled Phase III safety data for inclisiran showing safety and tolerability comparable to placebo and efficacy in line with the PCSK9 inhibitor class – which should be the reassurance it needs for the oral agent. 

Uninstalling Cholesterol
Inclisiran could offer patients twice-annual dosing

The Medicines Co. followed up its 26 August top-line readout for the Phase III ORION-11 trial of inclisiran with a full dataset that shows the short-interfering RNA (siRNA) therapy can offer LDL cholesterol-lowering capability similar to on-market PCSK9 inhibitors with twice-yearly dosing and a safety and tolerability profile similar to placebo.

Presenting the data at the European Society of Cardiology meeting on 2 September, The Medicines Co. asserted that inclisiran can be a market-disrupting LDL-C therapy that will address needs for...

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