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Tocagen On The Rocks With Phase III Brain Cancer Study Failure

 
• By Joseph Haas

The firm’s stock crashed on news that its Toca 511/Toca FC regimen did not show an overall survival benefit or meet any secondary endpoints in a Phase III study in recurrent high-grade glioma.

male doctor in studio, thumbs down, showing failed, bad news - Image
Tocagen's TOCA 5 trial missed the primary, all secondary endpoints

Faced with the total failure of its lead pipeline project, Toca 511/Toca FC (vocimagene amiretrorepvec), in its first late-stage trial, Tocagen Inc. is taking the loss on its chin. The San Diego biotech assured investors that it has confidence in the product and will review the data thoroughly, but it is also considering “all options” for the future.

Tocagen reported 12 September that Toca 511/Toca FC – a combination therapy comprising an injectable retroviral replicating vector and an...

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Pipeline Watch: Eight Approvals And Ten Phase III Readouts

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• By Joseph Haas

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