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Narrow HCC CheckMate-459 Miss For Opdivo Points The Way For Combos, Roche Shows How

 
• By Alexandra Shimmings

Full data at ESMO show Opdivo managed to scrape a tolerability edge over standard-of-care sorafenib in liver cancer, but eyes were drawn to Roche’s early study of Tecentriq/Avastin as the way forward in this difficult-to-treat cancer.

liver
IO combination therapy may be best in liver cancer. • Source: Shutterstock

The full results of Bristol-Myers Squibb Co.’s CheckMate-459 study show Opdivo missed out on producing an overall survival benefit in the face of a better-than-usual performance by the current standard of care Nexavar in first-line treatment of hepatocellular carcinoma (HCC).

Despite a clear tolerability advantage for Bristol's PD-1 inhibitor in the trial, which its researchers say tip the balance in...

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