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Lilly’s Pegilodecakin Fails Pancreatic Cancer Test

Asset came from $1.6bn Armo buy

 
• By Kevin Grogan

The company's immunotherapy failed to improve survival of pancreatic patients compared to chemotherapy. Lilly will be hoping pegilodecakin has more success in NSCLC.

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Sequoia falls but Lilly hopes Cypress studies fare better • Source: Shutterstock

Eli Lilly & Co.'s pegilodecakin, the lead immuno-oncology asset from its $1.6bn acquisition of Armo BioSciences Inc. last year, is the latest drug to fail as a potential therapy for notoriously difficult-to-treat pancreatic cancer.

The US major has announced top-line results from its Phase III SEQUOIA trial evaluating pegilodecakin, plus the widely-used FOLFOX (folinic acid, 5-fluorouracil and oxaliplatin) chemotherapy regimen compared to FOLFOX alone in patients with metastatic pancreatic cancer whose disease progressed following a first-line gemcitabine-containing regimen

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