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AstraZeneca’s Farxiga Approval In Heart Failure A First For SGLT2 Inhibitors

 
• By Leah Samuel

Farxiga, with a new indication to prevent hospitalization for heart failure in type 2 diabetes patients, is the first drug among the SGLT2 class to gain this indication outside of diabetics with renal disease.

Farxiga, a sodium-glucose cotransporter 2 (SGLT2) inhibitor from AstraZeneca PLC, may now be marketed in the US to reduce the risk of hospitalization for heart failure (hHF) in patients with type 2 diabetes, making it the first drug in its class to win a heart failure indication outside of diabetics with renal co-morbidities.

The US Food and Drug Administration (FDA) approved Farxiga on 21 October as a supplement to generic angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers and aldosterone antagonists to reduce the risk of hHF in adults with type 2 diabetes

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