Six Questions For TB Alliance CEO On Pretomanid And Pricing Issues

TB Alliance CEO Mel Spigelman outlines to Scrip the contours of the non-profit’s commercialization deal with Mylan for pretomanid, which is part of an oral combination regimen, and maintains that the $1/day pricing ask for the drug is based on flawed assumptions and not currently feasible.

Lung conference
Dr Mel Spigelman, President and CEO, TB Alliance • Source: TB Alliance

New treatments for drug-resistant tuberculosis (TB) have brought hope to patients, but access to these medicines and their pricing have been simmering issues in some resource-constrained high-burden markets.

The TB Alliance has been moving at a fast clip sewing up alliances to ensure an affordable, sustainable and competitive market for its new TB drug, pretomanid, approved in combination with Johnson & Johnson’s Sirturo (bedaquiline) and Pfizer Inc.’s Zyvox (linezolid) by the US FDA in August, for treating adult patients with extensively drug-resistant, treatment-intolerant or non-responsive multi-drug resistant pulmonary TB (MDR-TB)

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