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Novartis, Pfizer Advance Their NASH Ambitions Separately, As Partners

 
• By Joseph Haas

Novartis thinks tropifexor may prove to be best-in-class FXR agonist, while Pfizer notes the complementary activity of its ACC and DGAT2 inhibitors. Their NASH trial collaboration is heading toward a Phase II launch in 2020.

Liver Meeting Update, Boston 2019
Pfizer, Novartis are working to launching a Phase II NASH combo study in 2020

Neither Novartis AG nor Pfizer Inc. has entered Phase III in non-alcoholic steatohepatitis (NASH) yet, but it seems that the smaller companies ahead in development should be keeping a wary eye on the two big pharmas’ NASH programs, and not just because of their developing clinical trial partnership in the space.

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