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Kite Readies A Second CAR-T For Filing As CD19 Competition Grows

 
• By Mandy Jackson

The Gilead subsidiary presented updated data at ASH for its first CD19-targeting CAR-T Yescarta and pivotal results for KTE-X19, which it plans to submit for US FDA approval in mantle cell lymphoma this year. 

T Cell lymphocyte with receptors for cancer cell immunotherapy research 3D render
Kite will soon seek approval for its second T-cell therapy. • Source: Shutterstock

Gilead Sciences Inc. subsidiary Kite Pharma Inc. will file a biologic license application (BLA) for KTE-X19 with the US Food and Drug Administration by the end of this year, offering a second CD19-targeting chimeric antigen receptor T-cell (CAR-T) therapy for hard-to-treat lymphoma patients as one new competitor edges closer to launch and several other companies advance new technologies.

Kite presented pivotal trial results for KTE-X19 at the American Society of Hematology (ASH) meeting on 9 December in Orlando,...

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