Gilead Sciences Inc.’s hopes for being a player in non-alcoholic steatohepatitis (NASH) combination therapy took a hit on 16 December, as the Phase II ATLAS trial investigating monotherapy and combinations of three different drug candidates failed to meet statistical significance with any cohort on a fibrosis-reduction endpoint – raising questions about whether Gilead has a path forward with any of the agents studied in ATLAS.
Gilead’s Bad Luck In NASH Continues With ATLAS Failure
None of the two-drug combinations tested by Gilead met statistical significance in the multi-arm non-alcoholic steatohepatitis trial. This follows the Phase III failure of selonsertib monotherapy earlier in 2019.
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