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Wave Crashes Down On Duchenne Fail

Suvodirsen Terminated After Negative Trial

 
• By Kevin Grogan

Having spectacularly failed even to match Sarepta’s Exondys 51 in the restoration of dystrophin in Duchenne muscular dystrophy patients, Wave's future is dependent on soon-to-be published data on a Huntington’s disease therapy.

Waves breaking
Wave sunk by negative data • Source: Shutterstock

Shares in Wave Life Sciences Ltd. have hit the rocks after the company terminated development of suvodirsen following a dismal fail in a Duchenne muscular dystrophy trial.

The decision to discontinue suvodirsen came after an interim analysis of a Phase I open-label extension study in DMD patients...

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