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BeiGene's Brukinsa Fails In Head-To-Head But Hope Remains For Rare Indication

Signs Of Benefit Vs Imbruvica

 
• By Brian Yang

Days after bagging a US approval for its first global new drug, BeiGene was dealt a blow as its BTK inhibitor Brukinsa showed no significant superiority over class leader Imbruvica in Waldenström's macroglobulinemia, although the Chinese company remains hopeful for a possible approval.

Beijing
BEIJING-BASED BEIGENE'S BRUKINSA MISSES SUPERIORITY VS IMBRUVICA • Source: Shutterstock

BeiGene Ltd. disclosed results from the Phase III ASPEN trial that showed the company’s BTK inhibitor Brukinsa (zanubrutinib) missed its primary endpoint of superiority in terms of complete response and very good partial response (VGPR) in a head-to-head trial with AbbVie Inc.’s Imbruvica (ibrutinib).

But the Beijng-based company says it still intends to pursue discussions with regulators towards a possible approval in the study

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