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Unhappy New Year For Incyte With Itacitinib Flop

JAK1 Inhibitor Fails In Steroid-Naiïve Acute GVHD

 
• By Kevin Grogan

Incyte's hopes of reducing its reliance on Jakafi have suffered a blow after a Phase III trial of itacitinib failed. The stock has slumped and analysts are raising concerns about the company's ability to generate value from its hefty R&D investments.

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Another miss for Incyte • Source: Shutterstock

Incyte Corp.'s year has got off to a bad start with the company revealing that a late-stage study looking at itacitinib for treatment-naive acute graft-versus-host disease failed to reach its goal.

The Phase III GRAVITAS-301 study evaluating itacitinib, a selective JAK1 inhibitor, in combination with corticosteroids in patients with treatment-naive acute GVHD did not meet the primary endpoint of improving overall response rate at day 28 compared with placebo plus corticosteroids (74.0% vs 66.4%, respectively)

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