New Phase II Data Bolster vTv Therapeutics’ Glucokinase Activator Aspirations

Could Product Succeed Where SGLT2 Inhibitors Failed?

The future for glucokinase activation is looking brighter after fresh data on vTv’s oral adjunct to insulin therapy in type 1 diabetes.

liver
Liver selectivity key for glucokinase activators? • Source: Shutterstock

Further Phase II data for vTv Therapeutics Inc.’s leading glucokinase activator, TTP399, appear to lend support to the therapeutic strategy in improving glucose control in type 1 diabetics as an adjunct to insulin therapy.

Shares in the small High Point, NC-based firm shot up by more than 52% to $3.20 on the NASDAQ on the news on 10 February, as the second phase of the Simplici-T1 trial met its primary objective of improving blood sugar levels in 85 patients on optimized insulin therapy using either pumps or multiple daily injections of insulin

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