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CASPIAN Proves Too Choppy For AZ Imfinzi/Tremelimumab Combo

But Imfinzi Benefit Reinforced For Small Cell Lung Cancer

 
• By Kevin Grogan

Another day and another fail for AstraZeneca's combination of Imfinzi and tremelimumab, this time for extensive-stage small-cell lung cancer.

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CASPIAN not so serene for tremelimumab • Source: Shutterstock

AstraZeneca PLC's faith in the benefits of combining the firm's checkpoint inhibitor Imfinzi with its experimental anti-CTLA-4 monoclonal antibody tremelimumab has been shaken once again as it failed to improve overall survival in patients with late-stage small cell lung cancer (SCLC), although Imfinzi monotherapy did improve OS.

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