RESOLVE-IT Failure Dashes Genfit's NASH Hopes

Elafibranor Missed Trial Endpoints At The Interim Stage

12 May 2020

• By Sten Stovall

Genfit SA is now pinning its hopes for elafibranor on primary biliary cholangitis after the dual PPAR alpha/delta agonist failed in its Phase III RESOLVE-IT trial for NASH.

Target — RESOLVE-IT missed its primary endpoint for treating NASH • Source: Shutterstock

Genfit SA’s hopes of becoming one of the first companies to bring a NASH treatment to market were dashed on 11 May by news its keenly awaited Phase III RESOLVE-IT trial missed its primary endpoint.

The French biopharma’s lead asset, the dual PPAR alpha/delta agonist elafibranor, had been second in line behind Intercept Pharmaceuticals Inc.’s obeticholic acid, which is pending approval with a 27...

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