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DESTINY Calls For Daiichi Sankyo/AZ’s Enhertu In Other Indications

Gastric, Lung And Colorectal Data Promising

 
• By Alexandra Shimmings

Daiichi Sankyo and AstraZeneca’s ambitions to expand the use of their HER-2 targeted antibody-drug conjugate product beyond breast cancer are looking realizable on the back of new results presented at ASCO, but toxicities remain an issue. 

Digital illustration of lung cancer cells in color background
• Source: Shutterstock

New Phase II data for Daiichi Sankyo Co. Ltd./AstraZeneca PLC’s HER2-directed antibody-drug conjugate (ADC) Enhertu (trastuzumab deruxtecan) presented at ASCO reinforce its potential in three more tumor types where HER2 can play a role – gastric, lung and colorectal.

Enhertu was first launched for use in breast cancer in the US at the start of the year, but its potential in other cancer indications was a major factor in the multi-billion

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