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Pfizer’s Hopes For Ibrance In Adjuvant Breast Cancer Fall With PALLAS

 
• By Mary Jo Laffler

Ibrance (palbociclib) is unlikely to succeed in the adjuvant trial, the data safety monitoring board concluded. Pfizer has another adjuvant trial due later this year. 

Dividing breast cancer cell

Pfizer Inc.’s CDK4/6 inhibitor Ibrance (palbociclib) is now likely to miss out on the major chance for growth for the breast cancer drug, following the company’s announcement after the markets closed 29 May that the PALLAS study in adjuvant breast cancer was unlikely to meet the primary endpoint.

Pfizer had a two-year head start to establish Ibrance as the top drug in the CDK4/6 class, but it has been joined by Novartis AG’s Kisqali (ribociclib) and

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