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Roxadustat Stacks Up To Darbepoietin In Non-Dialysis Anemia

Plus Positive CV Signals

 
• By Ian Haydock

Astellas’s oral HIF-PH inhibitor shows non-inferiority to one established ESA in head-to-head trial and while there were cardiovascular benefits, the picture is complex.

Anemia medical diagram, abmormal blood cell count
New Comparative Results For Roxadustat • Source: Shutterstock

In the first data from a large Phase III trial comparing the efficacy and safety of one molecule in the wave of new hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) with an erythropoiesis-stimulating agent (ESA) in the non-dialysis setting, roxadustat has shown non-inferiority to darbepoietin alfa.

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