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ADC’s Phase II Data May Position ‘Lonca’ To Compete With Roche’s Polivy

 
• By Joseph Haas

The antibody-drug conjugate yields a 48% overall and 24% complete response rate in a pivotal Phase II DLBCL study. The Swiss biotech hopes to compete with Polivy and is studying combo therapy with Imbruvica.

Lymphoma cancer cell - 3d rendering
ADC Therapeutics thinks Lonca has broad potential across lymphoma settings

ADC Therapeutics SARL is aiming to file a biologics license application for its antibody-drug conjugate loncastuximab tesirine (ADCT-402, aka Lonca) in the second half of 2020 following presentation of Phase II data on 12 June showing solid overall response rates in third-line diffuse large B-cell lymphoma patients, including in patients who haven’t responded to prior therapy.

The ADC, which combines a CD19-targeting antibody with a second-generation pyrrolobenzodiazepine dimer delivery mechanism, yielded a 48.3% (70/145) overall response...

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