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Inventiva Moves Up In NASH, Hitting Multiple Phase IIb Endpoints

 
• By Joseph Haas

A month after Genfit’s Phase III failure, Inventiva hits multiple endpoints in a Phase IIb study of pan-PPAR agonist lanifibranor – likely drawing partnering or acquisition interest. Ascletis offers Phase II evidence for its NASH drug.

Excited multiracial colleagues celebrating team victory giving high five in office, happy employees group join hands together promising loyalty engagement, expressing trust unity support in teamwork
Inventiva may have moved toward the front of the pack in NASH with new data

One month after competitor Genfit SA crashed with a Phase III failure in NASH, Inventiva Pharma is moving toward the front of the pack in non-alcoholic steatohepatitis with Phase IIb data showing that its lanifibranor can improve hepatocellular inflammation and ballooning, reduce fibrosis and resolve NASH. The Daix, France-based firm noted it is the first company to meet both regulatory endpoints for NASH approval – resolution and fibrosis reduction – in the same clinical trial.

Lanifibranor, a pan-PPAR agonist, met its primary endpoint of reducing the Steatosis Activity Fibrosis (SAF) score from baseline at six...

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• By Joseph Haas

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• By Kevin Grogan

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