Inventiva Moves Up In NASH, Hitting Multiple Phase IIb Endpoints

A month after Genfit’s Phase III failure, Inventiva hits multiple endpoints in a Phase IIb study of pan-PPAR agonist lanifibranor – likely drawing partnering or acquisition interest. Ascletis offers Phase II evidence for its NASH drug.

Excited multiracial colleagues celebrating team victory giving high five in office, happy employees group join hands together promising loyalty engagement, expressing trust unity support in teamwork
Inventiva may have moved toward the front of the pack in NASH with new data

One month after competitor Genfit SA crashed with a Phase III failure in NASH, Inventiva Pharma is moving toward the front of the pack in non-alcoholic steatohepatitis with Phase IIb data showing that its lanifibranor can improve hepatocellular inflammation and ballooning, reduce fibrosis and resolve NASH. The Daix, France-based firm noted it is the first company to meet both regulatory endpoints for NASH approval – resolution and fibrosis reduction – in the same clinical trial.

Lanifibranor, a pan-PPAR agonist, met its primary endpoint of reducing the Steatosis Activity Fibrosis (SAF) score from baseline at six...

More from Clinical Trials

2025’s Biggest Launches – Half-Year Progress Report

 

Trial setbacks and extra regulatory scrutiny have hit the progress of some new drugs towards expected approvals this year, but early successes have boosted the commercial prospects of others. Fears of disruption from changes at the US FDA are so far unfounded.

Will AstraZeneca Reach Summit And Be A PD-1xVEGF Player?

 
• By 

Rumor mill suggests a $15bn licensing deal for ivonescimab is in the offing.

Compass Pathways’ Antidepressant Advances In An Increasingly Tough Psychedelic Market

 
• By 

Psychedelics appear to be in vogue after years of being relegated to alternative medicine. But investor pushback after the highly anticipated release of Phase III trial data by Compass Pathways reveals an increasingly high bar for development.

BioMarin’s Roctavian Continues to Shine In Hemophilia A Despite Commercial Woes

 

Roctavian shows durable bleed control and safety over five years, but high costs and access hurdles limit its commercial outlook.

More from R&D

BioMarin’s Roctavian Continues to Shine In Hemophilia A Despite Commercial Woes

 

Roctavian shows durable bleed control and safety over five years, but high costs and access hurdles limit its commercial outlook.

Dizal’s Zegfrovy Wins US NSCLC Approval, At Lower Dose Than In China

 

Dizal's EGFR inhibitor Zegfrovy approved in US as new once-daily oral option for second-line NSCLC with EGFR exon 20 insertion mutations, at lower dose than in China.

Novartis’s Cosentyx Suffers Rare Phase III Fail

 
• By 

Multi-blockbuster falls short in a giant cell arteritis study.