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Gilead’s Comparative Analysis To Bolster Remdesivir Draws Criticism

 
• By Joseph Haas

Gilead says remdesivir improved mortality and clinical recovery in COVID-19 patients, but the findings come from a retrospective analysis, not a traditional clinical trial.

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Gilead's retrospective analysis of remdesivir needs to be backed up by a traditional study

Gilead Sciences, Inc. is trying to clear up lingering questions about its COVID-19 therapeutic remdesivir with a new retrospective comparative analysis of its SIMPLE-Severe study, including showing a mortality benefit, which had not been evident in data used for global clearances for emergency use of the antiviral. But the select use of data without a controlled trial is drawing criticism.

The Foster City, CA-based company got a small stock bounce on 10 July after releasing retrospective comparative analysis data measuring remdesivir versus standard of care in patients hospitalized for COVID-19, but analysts and critics maintained that a traditional prospective trial is needed to confirm the company’s assertions of better clinical recovery and mortality outcomes with remdesivir

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