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Solid Phase I Results For AstraZeneca COVID-19 Vaccine, But Two Doses Needed To Hit Efficacy Goal

Investigators Highlight Promising T-Cell Response

 
• By Andrew McConaghie

Oxford’s long-awaited early stage study produces solid safety and efficacy results, but lags Pfizer/BioNTech and Moderna’s mRNA candidates for antibody response.

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Oxford is racing ahead in its Phase III trials, having dosed nearly all its target of 10,000 volunteers.

The University of Oxford and AstraZeneca PLC have released Phase I results from their COVID-19 vaccine, the early trial producing encouraging safety and efficacy signals, but a neutralizing antibody response that appears to be less strong than its rivals.

The study published in The Lancet of more than 1,000 healthy adult volunteers provides a solid base for the partners to continue with late-stage trials, with Oxford’s rapid progress into...

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