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Albireo Exits NASH, But Has Best-In-Class IBAT Opportunity

 
• By Joseph Haas

Elobixibat demonstrated ability to reduce LDL cholesterol but is being discontinued in NASH due to its unspectacular overall profile. The firm is staying focused on odevixibat, which could be best-in-class for pediatric liver indications, analysts say.

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Exiting NASH, Albireo now will put full focus on pediatric cholestatic diseases

Albireo Pharma, Inc. has determined that although its non-alcoholic steatohepatitis (NASH) candidate elobixibat reduced LDL cholesterol at statistical significance compared to placebo in a Phase II study, it is not continuing study of that drug in NASH because its overall therapeutic profile is “unremarkable.”

So even with a study that hit its primary endpoint, Albireo’s NASH program amounts to another setback in that disease,...

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