Early Success For 4D Pharma’s Microbiome Plus Keytruda Combination

Micro-Cap Stock Rises

After years of halting progress in its microbiome-based pipeline, 4D Pharma has produced promising early data from its cancer immunotherapy combination.

Bacteria
4D Pharma's 'live biotherapeutic' aims to activate a patient's immune system and enable a response to checkpoint inhibitor Keytruda

The results from 4D Pharma Plc's Phase I/II open-label trial of “live biotherapeutics” candidate MRx0518 in combination with Merck & Co., Inc.’s blockbuster Keytruda (pembrolizumab), suggest it could help refractory patients respond to cancer immunotherapy once again.

The Leeds, UK-based micro-cap company has been developing live bacteria therapies to treat a range of immune-related diseases (including irritable bowel syndrome and Crohn’s disease) since 2014, but a lack...

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