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Corbus Seeking Way Forward In Systemic Sclerosis After Phase III

Results For Placebo On Par With High-Dose Lenabasum

 
• By Mandy Jackson

The company explained that background immunosuppressant therapy performed better than anticipated based on scientific literature and physicians’ expectations. 

Dominoes
Lenabasum hit a roadblock in systemic sclerosis where results were similar to placebo • Source: Shutterstock

Corbus Pharmaceuticals Holdings, Inc.’s cannabinoid receptor type 2 (CB2) agonist lenabasum – the company’s only clinical-stage drug candidate – failed its first pivotal trial test, but the company is reviewing the data in hopes of finding a way forward for the drug in systemic sclerosis. Corbus said on 8 September that the similar results in the lenabasum and placebo arms of the Phase III clinical trial were due to background immunosuppressive therapy.

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