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Roche’s Ipatasertib Promising In Prostate, But Disappointing In Breast Cancer

Mixed Results In Pivotal Trials

 
• By Andrew McConaghie

Roche is hoping the investigational oral drug can help it expand its presence in breast cancer and break into the prostate cancer market – but the signals are decidedly mixed.

Metro
The ESMO congress had been planned to take place in Madrid this year, but like other meetings, went virtual because of the coronavirus pandemic.

Roche Holding AG looks well placed to break into the prostate cancer market with its novel small-molecule drug ipatasertib – but the signs are not so promising for the product in breast cancer, following disappointing results presented at the European Society for Medical Oncology cancer congress.

Ipatasertib is oral, highly specific, medicine designed to bind to all three isoforms of AKT (protein kinase B), to block the PI3K/AKT signalling pathway – a key driver of cancer...

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