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ESMO: A Tale Of Two CDK 4/6 Inhibitors With monarchE Success and Failure For PALLAS

Boost For Lilly, Blow For Pfizer

 
• By Alexandra Shimmings

Two different outcomes for two different CD4/6 inhibitors – Eli Lilly’s Verzenio and Pfizer’s Ibrance – put the Lilly drug on track to be a new standard of care in high-risk early stage HR+, HER2-negative breast cancer. Novartis’s Kisqali could follow.  

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• Source: Shutterstock

The differing fortunes of two cyclin-dependent kinase (CDK) 4/6 inhibitors – Eli Lilly and Company’s Verzenio (abemaciclib) and Pfizer Inc.’s Ibrance (palbociclib) – in early stage breast cancer were spelled out at the European Society for Medical Oncology meeting this weekend as the full results from the monarchE and PALLAS studies were presented.

Top-line data for both had already been reported, and suggested that Verzenio had succeeded where Pfizer’s product had failed in reducing the risk of breast cancer recurrence in women with hormone receptor-positive (HR+), human

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