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ESMO: Daiichi's HER3-Targeting ADC Shows Promise, Particularly In Resistant Tumors

Potential First-In-Class Agent

 
• By John Davis

HER3 may be a new target for anticancer antibody-drug conjugates; clinical investigators posted promising early stage clinical results with Daiichi Sankyo’s HER3 targeting antibody-drug conjugate, patritumab deruxtecan, at the recent ESMO virtual meeting. 

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Targeting HER3 May Be A Winning Strategy • Source: Shutterstock

Daiichi Sankyo Co., Ltd.’s potential first-in-class HER3 targeted antibody-drug conjugate (ADCs), patritumab deruxtecan, showed encouraging results in an early-stage clinical study reported at last week’s European Society of Medical Oncology (ESMO) virtual congress 2020, justifying the candidate therapeutic moving into Phase II trials earlier this month. 

Unlike HER2, the target for blockbuster-selling anticancers like Roche Holding AG’s Herceptin (trastuzumab), there are currently no therapeutic agents on the market that target HER3, a member of the EGFR family of tyrosine kinase inhibitors

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