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Janssen’s Amivantamab Combo Shows Promise In First-Line NSCLC

Tagrisso Head-To-Head Set To Begin

 
• By Jung Won Shin

Janssen presents highly encouraging interim results at ESMO from the CHRYSALIS study with a combination of amivantamab and lazertinib. Based on the data, the global Phase III MARIPOSA study, which will assess the combo versus blockbuster Tagrisso, will begin next month including in South Korea, home to lazertinib's originator. 

Doctor examining at lungs radiograph x-ray film of patient in operation room. medical concept.
Achieving Superiority Over Tagrisso Could Be Paradigm Changing • Source: Shutterstock

Janssen Pharmaceutical Cos. has unveiled very promising interim results from the CHRYSALIS study evaluating amivantamab, a bispecific antibody targeting epidermal growth factor receptor (EGFR) and mesenchymal epithelial transition factor (MET) mutations, in combination with the third-generation EGFR tyrosine kinase inhibitor (TKI) lazertinib, in patients with non-small cell lung cancer (NSCLC) with EGFR exon 19 deletions or L858R mutations.

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Henlius In David Versus Goliath Race With Pfizer For First PD-L1 ADC

 
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Camzyos nHCM Failure Could Open Door To Threat From Cytokinetics’ Aficamten

 
• By Alaric DeArment

BMS’s Phase III ODYSSEY-HCM study did not show statistical significance for either of its two primary endpoints.

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Henlius In David Versus Goliath Race With Pfizer For First PD-L1 ADC

 
• By Dexter Jie Yan

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AstraZeneca Logs Japan Growth Despite Price Cuts

 
• By Lisa Takagi

AstraZeneca logs growth in Japan despite a big reimbursement price cut for one of its top sellers and expects 40 approvals in the country over the next six years.

Camzyos nHCM Failure Could Open Door To Threat From Cytokinetics’ Aficamten

 
• By Alaric DeArment

BMS’s Phase III ODYSSEY-HCM study did not show statistical significance for either of its two primary endpoints.