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Selecta/Sobi Gout Drug Numerically, Not Significantly, Beat Krystexxa

SEL-212 Bested Horizon’s Drug But A New Standard Is Emerging

 
• By Mandy Jackson

Analysts have mixed opinions about whether a Phase IIb study of SEL-212, which Selecta recently licensed to Sobi, helps the drug’s commercial potential versus Horizon’s Krystexxa.

On a purple background a stethoscope with yellow list with text GOUT
Selecta and Sobi already have started Phase III trials for SEL-212 • Source: Shutterstock

Selecta Biosciences, Inc. and Swedish Orphan Biovitrum AB (Sobi) touted a successful conclusion of the Phase IIb COMPARE clinical trial, which showed that SEL-212 performed numerically better than Horizon Therapeutics plc’s Krystexxa (pegloticase) for chronic refractory gout. However, SEL-212 did not measure up to a new emerging standard of care for this patient population, so the drug candidate’s commercial prospects may be reduced.

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